Day 29: Elastography and Tissue Characterization – Imaging Beyond Anatomy

Welcome to Day 29!
Today we explore a modern advancement in ultrasound that adds functional insight to our structural images: Elastography — a technique that visualizes tissue stiffness. It helps differentiate benign from malignant lesions, assess fibrosis, and adds clinical value beyond grayscale imaging.


🧵 What is Elastography?

Elastography is a non-invasive ultrasound technique that evaluates tissue elasticity or stiffness by analyzing how tissue deforms under pressure.

In simple terms:
Soft tissue = deforms easily
Hard tissue = resists deformation


🧪 Why Tissue Stiffness Matters

  • Malignant tumors are generally stiffer than benign ones
  • Fibrotic livers (e.g., in chronic hepatitis) are less elastic
  • Inflamed or scarred tissues show altered elasticity

By assessing stiffness, elastography provides functional data to support diagnostic decision-making.


🧰 Types of Elastography

1. Strain Elastography

  • Applies manual compression to assess deformation.
  • Color-coded map:
    • Soft = red
    • Hard = blue
  • Semi-quantitative (uses strain ratios)

2. Shear Wave Elastography (SWE)

  • Uses focused acoustic pulses to generate shear waves.
  • Calculates tissue stiffness in kPa or m/s
  • Quantitative and operator-independent

SPI Tip:
Shear wave elastography is more reproducible and less user-dependent than strain imaging.


🏥 Clinical Applications of Elastography

Liver Fibrosis Staging
Breast Mass Evaluation
Thyroid Nodule Characterization
Prostate and Musculoskeletal Imaging
Lymph Node Assessment


🧠 Advantages of Elastography

  • Non-invasive alternative to biopsy in some cases
  • Adds diagnostic confidence in lesion evaluation
  • Can detect early fibrosis or subtle stiffness changes

⚠️ Limitations

  • Operator-dependent (especially in strain elastography)
  • May be affected by motion, depth, or lesion location
  • Not all machines or probes support elastography

📘 SPI Exam Essentials

✅ Elastography is based on tissue deformation under force
Strain elastography is qualitative/semi-quantitative
Shear wave elastography is quantitative and calculates velocity or stiffness
✅ Stiffer tissues = less displacement
✅ Expect image-based or concept MCQs


📝 Flashcard

Q: Which elastography method provides quantitative stiffness values in kPa or m/s?
A: Shear Wave Elastography


🧭 Conclusion

Elastography allows you to see what grayscale can’t — how tissue behaves under stress. It adds a new dimension to sonographic evaluation and will continue to grow in both clinical and registry settings. Get ready for Day 30, our final post — a complete SPI exam strategy and revision guide to bring it all together!

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